Supplementary data 4. SNP functional annotation and a list of the pleiotropic SNPs identified between 18 AiDs

We identified that the AiD associated SNPs are located in the non-coding regions of the genome. Of those, 186 are pleiotropic SNPs (<i>i.e., </i>same loci associated with multiple AiDs) that were associated with more than two AiDs. Majority of them (N=60) are shared between Crohn's disease (CRD) and Ulcerative colitis (ULC). We have presented a list of pleiotropic SNPs and the associated diseases in Table 2. For disease abbreviations, check Supplementary data 1.

我们发现，与自身免疫病（Autoimmune Diseases，AiD）相关的单核苷酸多态性（Single Nucleotide Polymorphisms，SNPs）位于基因组的非编码区域。其中，186个为多效性单核苷酸多态性（pleiotropic SNPs）（即与多种AiD相关的相同基因座），且与超过两种AiD相关。其中大多数（N=60）在克罗恩病（Crohn's disease，CRD）和溃疡性结肠炎（Ulcerative colitis，ULC）之间共享。我们已在表2中列出多效性SNPs及其相关疾病；有关疾病缩写，请查阅补充数据1。