Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]

Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.

利用Dynamic Loop模型的高级版本开展模拟实验，旨在探究染色质环化蛋白（chromatin looping proteins）CTCF和cohesin减少引发染色质压缩（chromatin compaction）这一实验发现背后的机制。