Data_Sheet_1_Nonlinear relationship between dietary calcium and magnesium intake and peripheral neuropathy in the general population of the United States.docx

BackgroundCalcium and magnesium are essential minerals that have significant roles in nerve function and regulation. There may be a correlation between dietary calcium and magnesium intake and peripheral neuropathy. However, this relationship remains unclear and requires further study.
MethodsData from 7,726 participants in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004 were analyzed in this study. The relationship between total dietary calcium and magnesium intake, as well as each quantile, and peripheral neuropathy was analyzed using a multifactor logistic regression model. To illustrate the dose–response relationship between calcium and magnesium intake and peripheral neuropathy, we utilized a restricted cubic spline (RCS) plot.
ResultsOur analysis found a positive correlation between dietary intake of calcium and magnesium and peripheral neuropathy (calcium: OR 1.000, 95% CI 1.000–1.000; magnesium: OR 1.001, 95% CI 1.00–1.002). Participants in the first and third quantiles of dietary calcium intake had a significantly higher incidence of peripheral neuropathy than those in the second quantile (OR 1.333, 95% CI 1.034–1.719, OR 1.497, 95% CI 1.155–1.941). Those in the first and third quantiles of dietary magnesium intake also had a significantly higher incidence of peripheral neuropathy than those in the second quantile (OR 1.275, 95% CI 1.064–1.528, OR 1.525, 95% CI 1.231–1.890). The restricted cubic spline analysis revealed a U-shaped nonlinear relationship between dietary intake of calcium and magnesium and peripheral neuropathy.
ConclusionThe study found a U-shaped non-linear relationship between dietary calcium and magnesium intake levels and peripheral neuropathy, indicating that both excessive and insufficient intake of calcium and magnesium can increase the incidence of peripheral neuropathy.

### 研究背景
钙与镁是对神经功能调控发挥关键作用的必需矿物质。膳食钙、镁摄入与周围神经病（peripheral neuropathy）之间可能存在关联，但该关联目前仍不明确，有待进一步研究。
### 研究方法
本研究分析了1999至2004年美国国家健康与营养检查调查（National Health and Nutrition Examination Survey, NHANES）中7726名参与者的相关数据。采用多因素logistic回归模型，分析膳食总钙、总镁摄入及其各分位数与周围神经病的关联；为直观呈现钙、镁摄入与周围神经病之间的剂量-反应关系，本研究使用了限制性立方样条（restricted cubic spline, RCS）图。
### 研究结果
本研究分析显示，膳食钙与镁的摄入与周围神经病呈正相关（钙：比值比（odds ratio, OR）=1.000，95%置信区间（confidence interval, CI）=1.000~1.000；镁：OR=1.001，95%CI=1.00~1.002）。膳食钙摄入处于第一和第三分位数的参与者，其周围神经病发病率显著高于第二分位数组（OR=1.333，95%CI=1.034~1.719；OR=1.497，95%CI=1.155~1.941）。膳食镁摄入处于第一和第三分位数的参与者，其周围神经病发病率同样显著高于第二分位数组（OR=1.275，95%CI=1.064~1.528；OR=1.525，95%CI=1.231~1.890）。限制性立方样条分析表明，膳食钙、镁摄入与周围神经病之间存在U型非线性关联。
### 研究结论
本研究发现，膳食钙与镁的摄入水平与周围神经病呈U型非线性关联，提示钙与镁摄入不足或过量均会增加周围神经病的发病风险。