Transforming Growth Factor-ß (TGFß) Prevents Hypertensive Aortic Dissection in Adult Mice via Extracellular Matrix Production (Bulk KO vs. WT Aorta)

We report bulk RNA-seq data of murine aortas at 1 week after conditional disruption of TGFß signaling in SMCs versus controls Overall design: Thoracic aortas were procured from untreated C57BL/6J (designated as WT) or tamoxifen-treated Tgfbr1f/f.Tgfbr2f/f.Myh11-CreERT2.mT/mG (designated as Tgfbr1/2iSMCKO or simply KO) mice, total RNA was isolated, and bulk RNA-seq analysis was performed

本研究报道了平滑肌细胞（smooth muscle cells, SMCs）中转化生长因子β（TGFβ）信号通路条件性敲除1周后的小鼠主动脉批量RNA测序（bulk RNA-seq）数据，并设置了平行对照组。实验设计概述：从未处理的C57BL/6J小鼠（标记为野生型WT）或经他莫昔芬处理的Tgfbr1f/f.Tgfbr2f/f.Myh11-CreERT2.mT/mG小鼠（命名为Tgfbr1/2iSMCKO，简称KO）中采集胸主动脉，分离总RNA并开展批量RNA测序分析。