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The detrimental effects of ultraviolet C (UVC) radiation on living organisms, with a specific focus on the fruit fly Drosophila melanogaster, were examined. This study investigated the impact of heightened UVC radiation exposure on D. melanogaster by assessing mortality and fertility rates, studying phenotypic mutations, and investigating the associated molecular mechanisms. The findings of this study revealed that UVC radiation increases mortality rates and decreases fertility rates in D. melanogaster. Additionally, phenotypic wing mutations were observed in the exposed flies. Furthermore, the study demonstrated that UVC radiation downregulates the expression of antioxidant genes, including superoxide dismutase (SOD), manganese-dependent superoxide dismutase (Mn-SOD), zinc-dependent superoxide dismutase (Cu-Zn-SOD), and the G protein-coupled receptor methuselah (MTH) gene. These results suggest that UVC radiation exerts a destructive effect on D. melanogaster by inducing oxidative stress, which is marked by the overexpression of harmful oxidative processes and a simultaneous reduction in antioxidant gene expression. In conclusion, this study underscores the critical importance of comprehending the deleterious effects of UVC radiation, not only to safeguard human health on Earth, but also to address the potential risks associated with space missions, such as the ongoing Emirate astronaut program.

本研究针对紫外线C（UVC）辐射对生物体的有害影响展开系统探究，重点聚焦于模式生物黑腹果蝇（Drosophila melanogaster）。本研究通过评估死亡率与生育率、分析表型突变以及探究相关分子机制，考察了强化UVC辐射暴露对黑腹果蝇的影响。研究结果显示，UVC辐射会提升黑腹果蝇的死亡率并降低其生育率；此外，受辐射暴露的果蝇体内出现了翅膀表型突变。进一步研究发现，UVC辐射会下调多种抗氧化基因的表达，其中包括超氧化物歧化酶（SOD）、锰依赖型超氧化物歧化酶（Mn-SOD）、锌依赖型超氧化物歧化酶（Cu-Zn-SOD）以及G蛋白偶联受体Methuselah（MTH）基因。上述结果表明，UVC辐射通过诱导氧化应激对黑腹果蝇产生破坏作用，该氧化应激以有害氧化过程的过度激活与抗氧化基因表达的同步下调为典型特征。综上，本研究强调了深入理解UVC辐射有害效应的极端重要性——这不仅关乎地球层面的人类健康保障，也有助于应对太空任务（如当前推进中的阿联酋宇航员项目）相关的潜在风险。