Regulation of oxidative stress in endothelial cells exposed to high glucose by selected microRNA. Homo sapiens

Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, endothelial dysfunction and vascular complications of diabetes. MicroRNAs (miRNAs) play a role in the development of endothelial dysfunction in diabetes, with potential application for the future therapy of diabetic vascular complications. However, there is a limited number of studies that characterize the miRNA profile of endothelial cells exposed to hyperglycemic condition. This study aimed to identify the miRNA profile of human umbilical vein endothelial cells (HUVEC) exposed to hyperglycemic state using RNA sequencing analysis.

高血糖是糖尿病的标志性特征，可引发氧化应激、内皮功能障碍及糖尿病血管并发症。微小RNA（microRNAs，miRNAs）在糖尿病内皮功能障碍的发生发展中发挥调控作用，具备应用于糖尿病血管并发症未来治疗的潜力。然而，目前针对高糖环境下内皮细胞的微小RNA表达谱进行表征的研究仍较为有限。本研究旨在通过RNA测序分析，鉴定高糖状态下人脐静脉内皮细胞（human umbilical vein endothelial cells，缩写HUVEC）的微小RNA表达谱。