Placental Growth Factor Regulates the Pentose Phosphate Pathway and Antioxidant Defense Systems in Human Retinal Endothelial Cells

The molecular mechanisms whereby placental growth factor (PlGF) mediates its effects in nonproliferative diabetic retinopathy (DR) are unknown. To better understand the role of PlGF in DR, we used tandem mass tags (TMT)-labeled quantitative proteomics to human retinal endothelial cells (HRECs), treated anti-PlGF antibody as a experimental, PBS as a control.

胎盘生长因子（PlGF）在非增殖性糖尿病视网膜病变（DR）中介导其生物学效应的分子机制目前尚不明确。为进一步阐明PlGF在DR中的作用，本研究采用串联质量标签（TMT）标记的定量蛋白质组学技术，对人视网膜内皮细胞（HRECs）分别以抗PlGF抗体处理作为实验组，以磷酸盐缓冲液（PBS）处理作为对照组。