Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders. Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders

We report two bulk transcriptomic datasets of striatum from male and female mice carrying either the 16p11.2 hemideletion of 3 genes hemideletion knockout within this region. Overall design: We performed bulk RNA sequencing gene expression analysis obtained from mouse striatum for two paradigms in both males and females: the full 16p11.2 hemideletion of 27 genes (16pdelhet vs. 16pdelhetWT) and the 3 genes knockout (3geneKOMut vs 3geneKOWT).

本研究报道了两批来自雌雄小鼠纹状体（striatum）的批量转录组数据集（bulk transcriptomic datasets），受试小鼠分别携带16p11.2半缺失（16p11.2 hemideletion），或该区域内3个基因的半缺失敲除（hemideletion knockout）。整体实验设计：我们针对雌雄小鼠的两种实验范式开展小鼠纹状体样本的批量RNA测序（RNA sequencing）基因表达分析：其一为包含27个基因的完整16p11.2半缺失模型（16pdelhet vs. 16pdelhetWT，即16p11.2半缺失杂合子与野生型对照）；其二为3个基因敲除模型（3geneKOMut vs. 3geneKOWT，即3基因敲除突变体与野生型对照）。