Gene expression profiling of CD4+ T cell subset from CARD11(E626K)CD4-Cre, HBZ Tg, and the compound mice.. Mus musculus strain:C57BL/6

To understand the basis of the ATL-like murine lymphoproliferative disease caused by CARD11(E626K) and HBZ expression, gene expression profiling of CD4+ T cell subsets from WT, CARD11(E626K) CD4-Cre, HBZ Tg, and CARD11(E626K) CD4-Cre; HBZ Tg mice were performed.

为阐明由CARD11(E626K)与HBZ表达所诱发的成人T细胞白血病（Adult T-cell Leukemia, ATL）样小鼠淋巴细胞增生性疾病的分子基础，本研究对野生型（Wild Type, WT）、CARD11(E626K) CD4-Cre、HBZ转基因（Transgenic, Tg）以及CARD11(E626K) CD4-Cre；HBZ Tg小鼠的CD4阳性T细胞亚群开展了基因表达谱分析。