Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [Bulk RNA-seq]. Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [Bulk RNA-seq]

To elucidate how the influence of Trem2-deficiency on adrenal gland gene expression during a model of chronic atherosclerosis Overall design: Whole adrenal gland transcript analysis from 12-week tamoxifen-high fat diet induced atherosclerosis in control or myeloid-specific conditional Trem2-deficient mice.

本研究旨在解析慢性动脉粥样硬化模型中，Trem2缺失（Trem2-deficiency）对肾上腺基因表达的影响。总体实验设计：选取经他莫昔芬联合高脂饮食诱导12周构建动脉粥样硬化模型的对照组小鼠与髓系特异性条件性Trem2缺失小鼠，采集其全肾上腺组织进行转录本分析。