Crosstalk between CYP2E1 and PPARa substrates and agonists modulate adipose browning and obesity

We report the discrepancy of hepatic mRNA expression in Cyp2e1 widetype and knockout mice by application of RNA-seq technology. Overall design: Hepatic mRNA profiles of Cyp2e1 wt and ko mice after fed with High-fat diet for 14 weeks

本研究采用RNA测序（RNA-seq）技术，解析了Cyp2e1野生型（wt，wildtype）与敲除型（ko，knockout）小鼠的肝脏mRNA表达差异。整体实验设计：对经14周高脂饮食饲喂的Cyp2e1野生型与敲除型小鼠的肝脏mRNA表达谱开展分析。