Number of true genes found and study cost as a function of filter, number of pedigrees, and number of sequenced individuals for model II (GRR = 15, number of susceptibility genes = 15).

GRR: genotype relative risk; nPeds: number of pedigrees sequenced; nCs: number of cases sequenced per pedigree; Cost is in million USD; nTrue: number of true susceptibility genes passed to the validation in stage II. Filters are described in Table 2.

GRR：基因型相对风险（genotype relative risk）；nPeds：测序家系数（number of pedigrees sequenced）；nCs：单家系测序病例数（number of cases sequenced per pedigree）；费用单位为百万美元；nTrue：传递至第二阶段验证的真实易感基因数量（number of true susceptibility genes passed to the validation in stage II）；筛选方法详见表2。