Novel One-Pot Multicomponent Strategy for the Synthesis of Pyrrolo[1,2-a]benzimidazole and Pyrrolo[1,2-a]quinoxaline Derivatives

A simple one-pot multicomponent procedure has been developed for the synthesis of pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]quinoxaline derivatives by heating a 1:2:1 molar mixture of a benzimidazole unsubstituted on the imidazole ring, a 2-bromoacetophenone derivative, and a nonsymmetrical activated alkyne in refluxing 2-ethyloxirane. The reaction can be performed under conventional reflux conditions or with microwave irradiation.

本研究开发了一种简便的一锅多组分合成方法，用于制备吡咯并[1,2-a]苯并咪唑（pyrrolo[1,2-a]benzimidazole）与吡咯并[1,2-a]喹喔啉（pyrrolo[1,2-a]quinoxaline）衍生物：将咪唑环未取代的苯并咪唑、2-溴苯乙酮衍生物与非对称活化炔烃按1:2:1的摩尔比混合，于回流状态的2-乙基环氧乙烷中进行加热反应。该反应既可通过常规回流条件实施，也可采用微波辐射辅助完成。