Table_1_Regulatory Roles of Related Long Non-coding RNAs in the Process of Atherosclerosis.DOCX

Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease, which comprise serious hazards to human health. Atherosclerosis is characterized by the deposition of lipids on the interior walls of blood vessels, causing an inflammatory response of immune cells, endothelial cells, and smooth muscle cells, and a proliferation cascade reaction. Despite years of research, the underlying pathogenesis of AS is not fully defined. Recent advances in our understanding of the molecular mechanisms by which non-coding RNA influences the initiation and progression of AS have shown that long non-coding RNAs (lncRNAs) regulate important stages in the atherosclerotic process. In this review, we summarize current knowledge of lncRNAs, which influence the development of AS. We review the regulatory processes of lncRNAs on core stages of atherosclerotic progression, including lipid metabolism, inflammation, vascular cell proliferation, apoptosis, adhesion and migration, and angiogenesis. A growing body of evidence suggests that lncRNAs have great potential as new therapeutic targets for the treatment of vascular diseases.

动脉粥样硬化（Atherosclerosis, AS）是冠心病、脑梗死以及外周血管疾病的主要致病因素，上述病症均对人类健康构成严重威胁。动脉粥样硬化以脂质在血管内壁沉积为核心特征，可引发免疫细胞、内皮细胞和平滑肌细胞的炎症反应，并触发增殖级联反应。尽管经过多年研究，动脉粥样硬化的潜在发病机制仍未完全阐明。近年来，学界对非编码RNA（non-coding RNA）调控动脉粥样硬化发生与发展的分子机制取得了新的研究进展，其中长链非编码RNA（long non-coding RNAs, lncRNAs）可调控动脉粥样硬化进程中的关键阶段。本综述总结了当前关于长链非编码RNA影响动脉粥样硬化发展的研究认知，梳理了长链非编码RNA在动脉粥样硬化进展核心阶段的调控机制，涵盖脂质代谢、炎症反应、血管细胞增殖、凋亡、黏附与迁移以及血管生成等多个方面。越来越多的研究证据表明，长链非编码RNA具备成为血管疾病新型治疗靶点的巨大潜力。