Hepatic cell lines, mode of transformation, tumorigenicity and sensitivity to rapamycin.

Mode of transformation and tumorigenicity are based on published data. IC50 for rapamycin was determined by [3H]-thymidine incorporation. Maximal inhibition (dose) refers to the lowest concentration of rapamycin at which maximal inhibition of [3H]-thymidine incorporation was observed. NNN, N-methyl-N'-nitro-N-nitrosoguanidine; GGT, gamma-glutamyl transpeptidase; THC, transplantable hepatocellular carcinoma. *, derived from the parental WB-F344 cell line.

转化与致瘤性的相关模式基于已发表的研究数据。雷帕霉素的半数抑制浓度（IC50）通过[3H]-胸腺嘧啶核苷掺入法测定。最大抑制效应（剂量）指可观测到[3H]-胸腺嘧啶核苷掺入受到最大程度抑制时的最低雷帕霉素浓度。NNN：N-甲基-N'-硝基-N-亚硝基胍（N-methyl-N'-nitro-N-nitrosoguanidine）；GGT：γ-谷氨酰转移酶（gamma-glutamyl transpeptidase）；THC：可移植性肝细胞癌（transplantable hepatocellular carcinoma）。* 源自亲本WB-F344细胞系。