The South Asian genome: Whole Genome Sequencing. Homo sapiens

The genetic sequence variation of people from the Indian subcontinent who comprise one-quarter of the world’s population, is not well described. The data provides the first comprehensive map of genetic variation in this major human population. Our results will accelerate the search for the genetic variants underlying susceptibility to disorders such as type-2 diabetes and cardiovascular disease which are highly prevalent amongst South Asians. The data contained within this project relates to the 40-50x coverage whole genome sequencing of 8 individuals.

占全球总人口四分之一的南亚次大陆(Indian subcontinent)人群，其遗传序列变异特征尚未得到充分阐明。本数据集首次构建了这一重要人类群体的遗传变异全景图谱。本研究成果将加速探寻南亚人群高发的2型糖尿病(type 2 diabetes)、心血管疾病(cardiovascular disease)等复杂疾病的易感遗传变异位点。本项目所涵盖的数据，来自对8名个体开展的40-50倍覆盖度(coverage)全基因组测序(whole genome sequencing)。