Expression data from murine lymphatic endothelial cells with angiotensin II treated. Expression data from murine lymphatic endothelial cells with angiotensin II treated

Proliferation and migration of lymphatic endothelial cells (LECs) are essential for lymphatic vessel growth (also known as lymphangiogenesis), which plays a critical role in regulating the tissue fluid balance and immune cell trafficking in physiological and pathological conditions. Overall design: In this study, murine LECs were stimulated with Ang II (500 nM) or saline for 12 or 24 hours. Cell proliferation and migration were determined. The gene expression profiles and signaling pathways were detected by time series microarray analysis.

淋巴管内皮细胞（lymphatic endothelial cells, LECs）的增殖与迁移，对于淋巴管生长（又称淋巴管新生）而言是必不可少的；而淋巴管生长在生理及病理状态下，对维持组织液平衡、调控免疫细胞转运均发挥关键作用。本研究的实验设计如下：将小鼠淋巴管内皮细胞分别以500nM的血管紧张素II（Ang II）或生理盐水刺激12小时或24小时，随后检测细胞的增殖与迁移能力，并通过时间序列微阵列分析检测其基因表达谱与信号通路。