ChIP-seq on KDM6A 786O cells

Here, we showed that KDM6A, an oxygen-dependent member of the histone demethylase family, regulates ferroptotic cell death by modulating expression of the critical ferroptosis effector. Overall design: KDM6A KO in 786O cell line

本研究发现，作为组蛋白去甲基化酶（histone demethylase）家族氧依赖性成员的KDM6A，可通过调控关键铁死亡（ferroptosis）效应分子的表达，调控铁死亡性细胞死亡。整体实验设计：在786O细胞系中进行KDM6A基因敲除。