Erratum: Major Depression and Psoriasis: A Psychodermatological Phenomenon

<b><i>Objective:</i></b> The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. <b><i>Method:</i></b> A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. <b><i>Results:</i></b> A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8. <b><i>Conclusion:</i></b> Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.

**研究目的**：本研究旨在阐明抑郁症与银屑病之间的相关发病机制及二者的关联。
**研究方法**：本研究通过多数据库全面检索文献，最终筛选出88项相关研究。
**研究结果**：本研究发现抑郁症与银屑病之间存在显著关联，其关联主要通过免疫介导机制实现，且不限于炎症细胞因子的调控作用，涉及的炎症细胞因子包括肿瘤坏死因子-α（tumor necrosis factor-α）、白细胞介素1（interleukin 1，IL-1）、IL-2、IL-10、γ干扰素（interferon-γ）、IL-1β、前列腺素E2（prostaglandin E2）、C反应蛋白（C-reactive protein）、IL-6及IL-8。
**研究结论**：多项神经免疫学研究均证实抑郁症与银屑病存在相互关联。褪黑素（melatonin）也被发现与这两种疾病均相关。鉴于银屑病与重性抑郁症之间可能存在双向关联，二者或可互为诱因。但仍有悬而未决的问题：为何并非所有抑郁症患者都会罹患银屑病，且并非所有银屑病患者都会患上抑郁症？我们认为，未来的研究将揭开这一谜团。