Death in Critical Asthma Mortality and Morbidity Planning Study

Death
Study Description
A retrospective study was conducted across the 8 children’s hospitals affiliated with the NICHD CPCCRN. All children between 1 and 18 years of age with critical asthma admitted to a PICU between January 1, 2005 and December 31, 2009 who required intubation and mechanical ventilation or who died were included. Critical asthma is defined as an acute exacerbation of asthma or status asthmaticus as the primary cause for PICU admission. Patients with cystic fibrosis or bronchiolitis were excluded. If a patient was admitted to the hospital more than once during the study period, each hospitalization for critical asthma in which the patient was intubated and mechanically ventilated was included as a case. If a patient was admitted to the PICU more than once during the same hospitalization, only the first PICU admission in which the patient was intubated and mechanically ventilated was included. The study was approved and waiver of informed consent granted by the Institutional Review Board at each site. Those patients aged between 1 and 18 years with a primary admitting diagnosis of an acute exacerbation of asthma or status asthmaticus, who are deemed ill enough to require admission to the PICU.

死亡结局相关研究描述
本研究为回顾性研究，覆盖隶属于美国国立儿童健康与人类发展研究所（National Institute of Child Health and Human Development, NICHD）儿科重症护理研究网络（Pediatric Critical Care Research Network, CPCCRN）的8家儿童医院。纳入2005年1月1日至2009年12月31日期间收入儿科重症监护病房（Pediatric Intensive Care Unit, PICU）、年龄1~18岁的重症哮喘患儿，且需接受气管插管与机械通气或最终死亡的病例。
重症哮喘被定义为以哮喘急性加重或哮喘持续状态为儿科重症监护病房收治首要病因的临床情况。
排除合并囊性纤维化或细支气管炎的患儿。
若研究周期内患儿多次因重症哮喘住院，每次需接受气管插管与机械通气的住院均作为独立病例纳入分析；若同一次住院期间患儿多次收入儿科重症监护病房，仅纳入首次接受气管插管与机械通气的儿科重症监护病房收治记录。
本研究已通过各研究机构审查委员会（Institutional Review Board, IRB）的审批，并豁免了知情同意要求。
本研究纳入对象为年龄1~18岁、以哮喘急性加重或哮喘持续状态为首要收治诊断、且病情危重需收入儿科重症监护病房的患儿。