Hesitation/Trust Differences.

BackgroundTissue Engineering (TE) is a newer technology with ongoing development across various areas of healthcare. For microtia patients, TE holds promise as a viable option for ear reconstruction, making it essential to understand the perspectives of patients and guardians. This study aimed to evaluate the perspectives of microtia patients and guardians, specifically investigating levels of awareness, comprehension, and interest in TE.MethodsA survey and educational material were distributed to microtia patients and guardians. Surveyors were assessed on a Likert scale, and comparative analyses, including two-sample t-testing and multivariate analysis with logistic regression, were used to observe trends in responses.ResultsA total of 40 surveys were recorded. White patients reported greater familiarity with TE. More than half of the respondents expressed an interest in TE as a reconstructive option. Having a doctor provide TE information positively correlated with willingness to adopt TE reconstruction. Understanding of TE positively correlated with willingness to pursue TE for reconstruction. Patients with more severe grade microtia and white patients were more likely to travel to a hospital that offered TE.ConclusionsWe found that TE is an unfamiliar concept for most patients. Demographic, socioeconomic, cost, and trust in a doctor played an essential role in patients’ and guardians’ willingness to choose TE for microtia reconstruction. As TE for reconstruction approaches clinical use, these key considerations from a patient and family-centered lens about TE-based reconstruction is critical for application.

背景：组织工程（Tissue Engineering，TE）是一项尚在各医疗领域持续发展中的新兴技术。对于小耳畸形患者而言，TE有望成为耳廓重建的可行方案，因此了解患者与监护者的态度至关重要。本研究旨在评估小耳畸形患者及监护者的态度，具体探究其对TE的认知程度、理解水平与兴趣度。
方法：针对小耳畸形患者与监护者，本研究发放了调查问卷与教育材料。以李克特量表对受访者的应答进行评估，并通过两独立样本t检验、logistic回归多变量分析等比较分析方法，观察应答数据的变化趋势。
结果：本研究共回收有效问卷40份。白人患者对TE的熟悉程度更高。超过半数的受访者表示对TE作为重建方案抱有兴趣。由医生提供TE相关信息，与患者愿意接受TE重建呈正相关。对TE的理解程度，与患者选择TE进行重建的意愿呈正相关。小耳畸形分级更严重的患者以及白人患者，更倾向于前往开展TE技术的医院就诊。
结论：本研究发现，TE对多数患者而言仍是一个陌生的概念。人口统计学特征、社会经济状况、治疗成本以及对医生的信任程度，均对患者与监护者选择TE进行小耳畸形重建的意愿有着重要影响。随着TE重建技术逐步走向临床应用，从患者与家庭视角出发的上述关键考量，对于TE重建技术的推广应用至关重要。