Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with compound 3q

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Helicobacter pylori in complex with compound 3q Descriptor: (3R)-hydroxymyristoyl-acyl carrier protein dehydratase, 4-tert-butyl-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazide, BENZAMIDINE, ... Authors: Zhang, L, He, L, Liu, X, Liu, H, Shen, X, Jiang, H. Deposit date: 2008-07-07 Release date: 2009-05-05 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J.Med.Chem., 52, 2009

幽门螺杆菌（Helicobacter pylori）来源的(3R)-羟酰基-酰基载体蛋白脱水酶（FabZ）与化合物3q复合物的晶体结构
描述符：(3R)-羟肉豆蔻酰基-酰基载体蛋白脱水酶、4-叔丁基-N'-[(1E)-(3,5-二溴-2,4-二羟基苯基)亚甲基]苯甲酰肼、苯甲脒（BENZAMIDINE）等
作者：张 L、何 L、刘 X、刘 H、沈 X、姜 H
存档日期：2008-07-07
发布日期：2009-05-05
最后修改日期：2023-11-01
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.3 Å
引用文献：《发现靶向幽门螺杆菌β-羟酰基-酰基载体蛋白脱水酶（FabZ）的强效抑制剂：基于结构的设计、合成、生物活性测定与晶体结构解析》，J.Med.Chem., 52, 2009