Histone tail modification profiles of human renal tubule epithelial cells

To annotate the regulatory elements in the renal tubule epithelial cells, we profiled 6 histone ChIP-seq in the human kidney epithelical cells (HKC8). Overall design: We pulled down the DNA with specific antibodies of interests against histone tail modifications in the human rebal tubule epithelial cells. The result can be interpretated with ChromHMM for different states.

为注释肾小管上皮细胞中的调控元件，我们对人肾小管上皮细胞（HKC8）开展了6组组蛋白染色质免疫共沉淀测序（ChIP-seq）分析。
实验设计：我们采用针对组蛋白尾部修饰的特异性目标抗体，对人肾小管上皮细胞中的DNA进行免疫沉淀富集。该测序结果可结合ChromHMM工具，用于解析不同的染色质状态。