Genetic and Antigenic Characterization of Enterovirus 71 in Ho Chi Minh City, Vietnam, 2011

Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.

肠道病毒71型（Enterovirus 71, EV71）是亚洲地区引发幼儿致死性感染的常见病原体。2011年，越南南部暴发了EV71疫情。本研究对此次疫情中分离得到的EV71毒株开展了遗传与抗原性分析，结果显示其中94%为C4a基因型，与在中国境内流行的两个毒株谱系相关；剩余6%为C5基因型，该基因型自2003年起便在越南境内持续流行。本次分析未检测到抗原变异株。目前针对EV71的疫苗正处于研发阶段。纵向肠道病毒监测数据对于越南制定疫苗接种策略具有至关重要的意义。