Structure and Evaluation of Nanodrug Hydrogel Delivery Systems for Psoriasis Treatment using Rheo-SANS

The experiments will evaluate and optimise a novel smart controlled release injectable liposomal hydrogel drug delivery systems from low cost precursors, Pluronic F-127 and chitosan. The matrix’s sol-gel phase transition in the body allows them to be administered as drug loaded solutions before transforming to soft gel depots at body temperature, then release the drug over a designed time. liposomes structural similarity to cells allows for enhanced drugs bioavailability and increased blood circulation time. The proposed systems are designed to regulate the release of Secukinumab® for the treatment of plaque Psoriasis, aiming to reduce cost, dosing frequency and enhance patients’ compliance. The requested beamtime will allow us to investigate the effects of combined shear and extensional flow as experienced during real bodily administration on the system's morphology and stability.

本实验旨在评估并优化一种基于低成本前体材料Pluronic F-127和壳聚糖（chitosan）的新型智能控释注射用脂质体水凝胶药物递送系统（smart controlled release injectable liposomal hydrogel drug delivery system）。该基质在体内的溶胶-凝胶相变（sol-gel phase transition）特性使其可作为载药溶液给药，进入体温环境后转化为软凝胶储库，并在预设时间内实现药物释放。脂质体（liposomes）与细胞的结构相似性有助于提高药物生物利用度并延长血液循环时间。所提出的系统旨在调控司库奇尤单抗（Secukinumab®）的释放以治疗斑块状银屑病（plaque Psoriasis），目标是降低成本、减少给药频率并提高患者依从性。申请的束流时间（beamtime）将使我们能够研究体内实际给药过程中遇到的剪切-拉伸复合流对该系统形态与稳定性的影响。