Homo sapiens Transcriptome or Gene expression

The induced pluripotent stem-like cells from human gastric cell line, KMU-CS12 (CS12) were derived from putative human gastric stem cell/progenitor cell clone. CS12 expressed cancer cell phenotypes, i.e. the ability of anchorage-independent growth high frequency (44%) and to the expression of Oct4, a stemness marker and many types of cancer cells, and tumor development in immune deficient mice.

源自人胃细胞系KMU-CS12（简称CS12）的诱导多能干细胞样细胞（induced pluripotent stem-like cells），由推定的人胃干细胞/祖细胞克隆诱导得到。CS12表现出癌细胞表型：其一，具备44%的高频率非锚定依赖性生长（anchorage-independent growth）能力；其二，表达作为干细胞干性标志物（stemness marker）的Oct4及多种癌细胞相关特征；其三，可在免疫缺陷小鼠（immune deficient mice）体内形成肿瘤。