Spearman Correlation on categorical, nominal data and Pearson correlation on continuous data.

Table 4 shows the results of the Spearman Correlation on categorical, nominal data and Pearson correlation on continuous data. Variables that are ordinal were analyzed with Spearman correlation without and with the Bonferroni correction and continuous variables were analyzed using Pearson correlation without and with the Bonferroni correction. In the top row only biomarkers that were significantly correlated to patient groups have been included. Thus, each biomarker value was first correlated to the three groups: RRMS & SC, PPMS & SC, and CIS & SC, and then further correlated to all the demographic parameters. The correlation coefficient, r, is displayed with the significance levels indicated both without / and with the Bonferroni correction by * for p<0.05, and ** for p<0.001. All p-values are presented in tables B-Y in S1 Dataset. Abbreviations: RRMS (relapsing-remitting MS), PPMS (primary-progressive MS), CIS (clinically isolated syndrome), SC (symptomatic controls), n (number of persons), CSF (cerebrospinal fluid), NfL (neurofilament light polypeptide), TNL (total number of MRI white matter lesions), NEO (neopterin), OPN (osteopontin).
Spearman Correlation on categorical, nominal data and Pearson correlation on continuous data.

表4展示了针对分类名义数据的斯皮尔曼相关性分析（Spearman Correlation），以及针对连续型数据的皮尔逊相关性分析（Pearson Correlation）的结果。有序变量采用未校正与经邦弗朗尼校正（Bonferroni correction）的斯皮尔曼相关性分析，连续变量则采用未校正与经邦弗朗尼校正的皮尔逊相关性分析。本表格首行仅纳入与患者分组存在显著相关性的生物标志物（biomarker）。具体分析流程为：首先将每一种生物标志物的数值与三组对照分别进行相关性分析，即复发缓解型多发性硬化（RRMS, relapsing-remitting MS）与症状对照（SC, symptomatic controls）、原发进展型多发性硬化（PPMS, primary-progressive MS）与症状对照、临床孤立综合征（CIS, clinically isolated syndrome）与症状对照；随后再将生物标志物与所有人口统计学参数进行相关性分析。相关性系数r已列出，显著性水平的标注规则如下：未校正与经邦弗朗尼校正的结果中，*代表p<0.05，**代表p<0.001。所有p值均见于补充数据集1（S1 Dataset）中的表B至表Y。缩写说明：RRMS（relapsing-remitting MS）、PPMS（primary-progressive MS）、CIS（clinically isolated syndrome）、SC（symptomatic controls）、n（number of persons）、CSF（cerebrospinal fluid）、NfL（neurofilament light polypeptide）、TNL（total number of MRI white matter lesions）、NEO（neopterin）、OPN（osteopontin）。针对分类名义数据的斯皮尔曼相关性分析，以及针对连续型数据的皮尔逊相关性分析。