Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia

Fibrosis is the pathophysiological hallmark of progressive chronic kidney disease (CKD). The kidney is a highly metabolically active organ, and disruption in its metabolism could lead to renal fibrosis and disease progression. We developed a longitudinal mouse model of acute kidney injury leading to chronic kidney disease and an in vitro model of epithelial to mesenchymal transition and generated transcriptomics on kidney tissue and tubular cells at different time points.

纤维化是进行性慢性肾脏病（CKD）的病理生理特征。肾脏是代谢活性极高的器官，其代谢紊乱可引发肾纤维化并促进疾病进展。本研究构建了可进展为慢性肾脏病的急性肾损伤纵向小鼠模型，以及上皮间质转化（epithelial to mesenchymal transition）的体外模型，并获取了不同时间点肾脏组织与肾小管细胞的转录组学数据。