Research data supporting "KV7 but not dual SK/IK channel openers inhibit the activation of colonic afferents by noxious stimuli"

This data pertains to a PhD project investigating the role of calcium-activated potassium channels and a subfamily of voltage-gated potassium channels (Kv7) in the regulation of colonic afferent activity. Fig 1 shows the expression of transcripts encoding channel subunits (derived from publicly-available RNAseq dataset). Figs 2-5 shows electrophysiological data from experiments in which the activity of the lumbar splanchnic nerve was recorded while chemical or mechanical stimuli were applied to the colon. Fig 6 shows analysis of experiments in which the intraluminal pressure of the colon was recorded. All data sheets are labelled to show the corresponding figure panel.

本数据集源自一项博士研究课题，该课题旨在探究钙激活钾通道（calcium-activated potassium channels）与电压门控钾通道Kv7亚家族（voltage-gated potassium channels Kv7 subfamily）在结肠传入活动调控中的作用。图1展示了编码通道亚基的转录本表达情况，相关数据取自公开可用的RNA测序（RNAseq）数据集。图2至图5展示的电生理数据来自以下实验：向结肠施加化学或机械刺激的同时，记录腰内脏神经（lumbar splanchnic nerve）的活动。图6则对结肠腔内压力记录实验的结果进行了分析。所有数据表均标注了对应的图面板编号。