Identification and validation of centrosome-related features predicting prognosis in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is commonly linked with centrosome abnormalities that contribute to chromosomal instability and tumor progression. Four prognostic centrosome-related genes (CRGs): DYNLL1, CEP85, C10orf90, and CETN1 were utilized to develop a risk model for HCC. The model demonstrated strong prognostic reliability. Both risk score and risk group served as independent prognostic predictors for HCC. Further analyses revealed that the low-risk group was associated with metabolism and detoxification pathways and exhibited a lower abundance of M2 macrophages. Additionally, high expression levels of DYNLL1 and CETN1 were significantly correlated with poorer prognosis, with upregulation of DYNLL1 confirmed in HCC patients.

肝细胞癌（hepatocellular carcinoma, HCC）常与中心体异常相关，而后者可促进染色体不稳定性与肿瘤进展。本研究选取DYNLL1、CEP85、C10orf90及CETN1这4个中心体相关预后基因（centrosome-related genes, CRGs），用于构建肝细胞癌的风险预测模型。该模型具备良好的预后预测可靠性。风险评分与风险分组均可作为肝细胞癌独立的预后预测因子。进一步分析显示，低风险组与代谢及解毒通路显著相关，且其M2型巨噬细胞的浸润丰度更低。此外，DYNLL1与CETN1的高表达均与不良预后显著相关，且已有研究证实HCC患者体内DYNLL1存在表达上调现象。