MOESM4 of Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

Additional file 4: Table S6. Gene ontology enrichment analysis of 0→5 and 5→10 dmCpGs. Enrichments were calculated from the difference between the dmCpGs obtained in each of the analyses and the GO ontology database by the R/Bioconductor package missMethyl. Ontologies for genes with 1) both hyper- and hypomethylated probes 2) exclusively either hyper- or hypomethyated and 3) from mapped hyper- or hypomethylated dmCpGs which did not take into account CpGs differentially methylated in the opposite direction in the same genes are included. Also included are the ontologies found when analyzing 0→5 dmCpGs grouped by gene region (promoter, exon, intron and gene body). All of the analyses include “molecular function”, “cellular component” and “biological process” terms.

附加文件4：补充表S6。针对0→5与5→10区间差异甲基化CpG位点（dmCpGs）的基因本体论富集分析。富集分析结果通过R/Bioconductor工具包missMethyl，基于各分析中获取的dmCpGs与基因本体论（Gene Ontology，GO）数据库的差异值计算得到。本次分析纳入的基因本体论分析对象包含三类：1）同时携带高甲基化与低甲基化探针的基因；2）仅携带高甲基化探针或仅携带低甲基化探针的基因；以及3）源自已注释的高/低甲基化dmCpGs、且未考虑同一基因内反向差异甲基化CpG位点的基因。此外还纳入了按基因区域（启动子、外显子、内含子及基因体）分组的0→5区间dmCpGs分析所得的基因本体论结果。所有分析均涵盖分子功能（molecular function）、细胞组分（cellular component）及生物过程（biological process）三类本体术语。