Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

This is a window-of-opportunity umbrella platform trial enrolling non-metastatic resectable colorectal patients selected for the presence of a specific targetable molecular alteration. The study aims to test the activity of specific targeted agents/combinations given as a short-course pre-operative strategy, matched with the specific alteration detected, followed by standard of care surgery.

本试验为一项机会之窗式伞式平台试验（window-of-opportunity umbrella platform trial），纳入经筛选携带特定可靶向分子改变的非转移性可切除结直肠癌患者。本研究旨在评估与检测到的特定分子改变相匹配的、以短期术前治疗策略给药的靶向药物/联合方案的抗肿瘤活性，随后为患者实施标准治疗手术。