Starr County T2D-GENES Exome Sequencing Study

T2D-GENES (Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples) is a NIDDK-funded international research consortium which seeks to identify genetic variants for type 2 diabetes (T2D) through multiethnic sequencing studies. T2D-GENES Project 1 is a multi-ethnic sequencing study designed to assess whether less common variants play a role in T2D risk and to assess similarities and differences in the distribution of T2D risk variants across ancestry groups. The individuals were obtained from 14 cohorts that are listed in Table 1. The strategy was to perform deep exome sequencing of 12,940 individuals, 6,504 with T2D and 6,436 controls, divided among five ancestry groups: Europeans, East Asians, South Asians, American Hispanics, and African Americans. Sequencing was performed at the Broad Institute using the Agilent v2 capture reagent on Illumina HiSeq machines. Please note that while we summarize the full sample list... (for more see dbGaP study page.)

T2D-GENES（基于多族群样本下一代测序的2型糖尿病遗传探索研究，Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples）是由美国国家糖尿病、消化与肾脏疾病研究所（National Institute of Diabetes and Digestive and Kidney Diseases, NIDDK）资助的国际研究联盟，旨在通过多族群测序研究识别与2型糖尿病（type 2 diabetes, T2D）相关的遗传变异。T2D-GENES项目1（T2D-GENES Project 1）为一项多族群测序研究，旨在评估低频变异是否参与2型糖尿病患病风险的调控，并解析不同祖先群体间2型糖尿病风险变异的分布差异与共性。本研究的研究对象来自表1所列的14个队列，共纳入12940名受试者，其中2型糖尿病患者6504名、健康对照个体6436名，且按祖先族群划分为5组：欧洲裔、东亚裔、南亚裔、拉美裔美国人以及非裔美国人。测序工作由博德研究所（Broad Institute）完成，实验采用安捷伦v2捕获试剂（Agilent v2 capture reagent），测序平台为Illumina HiSeq系列测序仪。请注意，本说明仅对完整样本列表进行了概要总结……（完整详情请参见dbGaP研究页面）