Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation [bulk ATAC-seq]

To investigate the regulation of human enteroendocrine cell differentiation, we established Neurog3ER inducible cell lines. We then performed chromatin analysis using data obtained from ATAC-seq of 2 independent human lines at various time points. ATAC-seq of 2 independent human lines at various time points.

为探究人类肠内分泌细胞分化的调控机制，我们构建了Neurog3ER诱导性细胞系。随后，我们利用两个独立的人类细胞系在不同时间点获取的转座酶可及性染色质测序（Assay for Transposase-Accessible Chromatin using sequencing，简称ATAC-seq）数据开展染色质分析。