Analysis of Entropy of sequences and epitope-specific functional responses based on the order of time of appearance of epitope mutations within each individual.

a.The position refers to the position in the HXB2 sequence.
b.Optimal defined or predicted epitopic sequences are reported in bold.
c. "Undetermined": no epitopes recognized within restricting alleles expressed by the patients have been previously reported.
d. Indicates time of the earliest frequency of response detected by ICS assay.
e. Virus load (VL) detected at the correspondent week of T cell response (d) is reported in copies/ml.
f. The letters indicate the ranking based on appearance of escape mutations or lack thereof. The same letter are used in Figure 5 to indicate the correspondent epitope.
g. Epitopes dysplaying mutations related to T cell responses and evidence for variation escape within 55 and 87 WFOSx are listed as early (e-ME) or late (l-ME), respectively; those without evidence for variation and escape are reported as nME. Escape mutant epitopes are listed in order of appearance within each subject.
h. The numbers reflect the Shannon entropy as indicated in the Methods section. The higher is the value, the higher is the likelihood for the region to allow for variability in the sequence.
i. Each column reports the frequency (Freq) of the population of interest as % of total memory CD8+ T cells.

a. 此处的位置指HXB2序列（HXB2 sequence）中的对应位点。
b. 经明确界定或预测得到的最优表位序列以粗体形式呈现。
c. "未确定（Undetermined）"：此前尚未见针对患者所表达的限制性等位基因所识别的表位的相关报道。
d. 代表通过ICS检测所检出的最早响应频率对应的时间点。
e. 与T细胞响应对应周数（即标注d的条目）同步检出的病毒载量（VL, Virus Load）以拷贝/毫升为单位报告。
f. 字母代表基于逃逸突变出现与否进行的排序；图5中使用相同字母标注对应的表位。
g. 与T细胞响应相关且在55和87 WFOSx内存在变异逃逸证据的表位，分别归类为早期逃逸突变表位（e-ME）和晚期逃逸突变表位（l-ME）；无变异及逃逸证据的表位则标注为nME。每个受试者体内的逃逸突变表位按出现顺序排列。
h. 数值代表方法学章节中提及的香农熵（Shannon entropy）；该数值越高，对应区域序列发生变异的可能性就越大。
i. 每一列均报告目标细胞群体占总记忆性CD8+ T细胞的百分比（Freq, Frequency）。