Data_Sheet_1_Neural effects of multisensory dance training in Parkinson’s disease: evidence from a longitudinal neuroimaging single case study.pdf

Dance is associated with beneficial outcomes in motor and non-motor domains in Parkinson’s disease (PD) and regular participation may help delay symptom progression in mild PD. However, little is known about the neurobiological mechanisms of dance interventions for PD. The present case study explored potential neuroplastic changes in a 69-year-old male with mild PD participating in regular dance classes over 29 weeks. Functional MRI was performed at four timepoints (pre-training, 11 weeks, 18 weeks, 29 weeks), where the individual imagined a dance choreography while listening to the corresponding music. Neural activity was compared between dance-imagery and fixation blocks at each timepoint. Analysis of functionally defined regions revealed significant blood-oxygen-level-dependent (BOLD) signal activation in the supplementary motor area, right and left superior temporal gyri and left and right insula, with modulation of these regions observed over the training period except for the left insula. The results suggest the potential for dance to induce neuroplastic changes in people with PD in regions associated with motor planning and learning, auditory processing, rhythm, emotion, and multisensory integration. The findings are consistent with dance being a multimodal therapeutic activity that could provide long-term benefits for people with PD.

舞蹈与帕金森病（Parkinson’s Disease，PD）患者的运动及非运动领域获益结局密切相关，规律参与舞蹈活动或有助于延缓轻度帕金森病患者的症状进展。然而，目前针对帕金森病舞蹈干预的神经生物学机制仍知之甚少。本项个案研究对一名参与29周规律舞蹈课程的69岁轻度帕金森病男性患者的潜在神经可塑性变化展开了探索。研究在四个时间节点（训练前、第11周、第18周、第29周）对受试者进行了功能磁共振成像（functional MRI）扫描：扫描期间，受试者需在聆听对应音乐的同时，想象指定的舞蹈编排。在各时间节点下，均对舞蹈想象任务与注视基线任务区块的神经活动开展了对比分析。对功能定义脑区的分析结果显示，辅助运动区、双侧颞上回以及双侧脑岛均出现了显著的血氧水平依赖（blood-oxygen-level-dependent, BOLD）信号激活；且除左侧脑岛外，其余脑区的激活水平在整个训练周期中均呈现出动态调节变化。本研究结果表明，舞蹈或可诱导帕金森病患者在与运动规划与学习、听觉加工、节律感知、情绪处理及多感觉整合相关的脑区内产生神经可塑性变化。上述研究结果与“舞蹈是一种多模态治疗活动，可为帕金森病患者带来长期获益”的观点相一致。