Two-/three-dimensional coordination polymers: structural characterization and treatment activity on ulcerative colitis by regulating inflammatory cytokines

In the current study, two new mixed-ligand coordination polymers with the chemical formulae of {[Co(L1)0.5(oba)·DMF]·DMF·H2O} (1, L1 = N,N′-bis(4-pyridylmethyl)-naphthalene diimide, H2oba = 4,4′-oxydibenzoic acid) and [Co(L2)0.5(OBA)]n (2, L2 = 1,6-bis(benzimidazolyl)hexane) have been successfully synthesized by the solvothermal reaction of H2oba with different flexible N-donor organic ligands in the presence of Co(NO3)2·6H2O as the metal source. In addition, the biological functional evaluation of the complexes was performed on the ulcerative colitis (UC) model. First, the enzyme-linked immunosorbent assay detection kit was performed to measure the content of the pro-inflammatory cytokines and anti-inflammatory cytokines after complexes treatment. Next, the UC mice model was constructed and the body weight of the mice was measured and recorded at the 7th and 14th day after complexes treatment at the concentration of 5 mg/kg.

本研究中，以Co(NO₃)₂·6H₂O为金属源，通过H₂oba与不同柔性氮供体有机配体的溶剂热反应，成功合成了两种新型混合配体配位聚合物，其化学表达式分别为{[Co(L1)₀.₅(oba)·DMF]·DMF·H₂O}（1，其中L1 = N,N′-双(4-吡啶甲基)萘二酰亚胺，H₂oba = 4,4′-氧联二苯甲酸）与[Co(L2)₀.₅(OBA)]ₙ（2，其中L2 = 1,6-双(苯并咪唑基)己烷）。此外，本研究针对上述配合物开展了基于溃疡性结肠炎（UC）模型的生物学功能评价：首先采用酶联免疫吸附检测试剂盒，测定配合物处理后样本中促炎细胞因子与抗炎细胞因子的含量；随后构建UC小鼠模型，在以5 mg/kg浓度的配合物给药后第7天及第14天，测量并记录小鼠体重。