STUDY ON MOLECULAR MECHANISMS UNDERLYING TUMOUR ANGIOGENESIS

Cancer, acomplexdisorder marked by the aberrant proliferation of cells independent of physiological organ connections, represents a multifaceted, multi-stage, and multi-mechanistic phenomenon. Its onset, progression, and manifestation involve intricate interplays between environmental and host factors. Inherited genetic predispositions notably contribute to 5-10 percent of breast cancer and 5-13 percent of colon cancer cases. Within industrialized nations, approximately 7 percent of cancer-related deaths are linked to viral infections, 4 percent to occupational hazards, 2 percent to sunlight exposure, 2 percent to air, water, and soil pollution, and less than 1 percent to constituents in food and industrial products. This review offers a comprehensive examination of ongoing research concerning the micro-metastatic state in solid tumors.

癌症是一类以细胞异常增殖且不依赖生理器官的调控连接为特征的复杂疾病，属于多维度、多阶段、多机制的病理现象。其发生、进展及临床表现涉及环境因素与宿主因素之间复杂的相互作用。遗传性易感倾向可分别导致5%-10%的乳腺癌病例与5%-13%的结直肠癌病例。在工业化国家中，约7%的癌症相关死亡与病毒感染相关，4%与职业危害有关，2%与日光暴露相关，2%与空气、水及土壤污染相关，另有不足1%与食品及工业产品中的成分相关。本综述对实体瘤微转移状态的现有研究进展进行了全面梳理与探讨。