Identified differentially expressed lncRNAs in Type 1 Diabetes Patients

Long noncoding RNAs (lncRNAs) is already evidently involved in a variety of biological functions and pathophysiological mechanisms underlying the diabetes. However, the role of lncRNAs in the type 1 diabetes (T1D) has not been explored clearly yet. The aim of this study was to determine the circulating lncRNA profile and confirmed the differentially expressed lncRNA between T1D patients and healthy control. Overall design: Leukocyte lncRNA profiles of healthy control and T1D patients were generated by deep sequencing

长链非编码RNA（long noncoding RNAs，lncRNAs）已被证实广泛参与多种生物学功能及糖尿病相关病理生理机制。然而，长链非编码RNA在1型糖尿病（type 1 diabetes，T1D）中的作用尚未得到清晰阐释。本研究旨在明确循环长链非编码RNA表达谱，并鉴定1型糖尿病患者与健康对照之间的差异表达长链非编码RNA。实验整体设计：通过高通量测序获取健康对照及1型糖尿病患者的白细胞长链非编码RNA表达谱。