Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection

Introduction: The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression. Methods: Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation. Results: Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis. Conclusions: HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.

引言：丙型肝炎病毒（hepatitis C virus, HCV）的基因组异质性可影响肝脏疾病发生发展。本研究旨在明确HCV基因型的流行率，并探究此类基因型对疾病进展的影响。
方法：从HCV血清学阳性患者中采集血液样本与肝活检组织，用于血清学分析、生化标志物检测、HCV基因分型及组织病理学评估。
结果：共在107例患者中检测到丙型肝炎病毒核糖核酸（hepatitis C virus-ribonucleic acid, HCV-RNA），其中基因型1型占比90.6%，基因型3型占比9.4%。感染基因型1型的患者平均坏死性炎症活动度与纤维化程度更高。
结论：HCV基因型1型为最流行的基因型，且与更显著的肝脏功能异常相关。