Serological evidence of lyssaviruses among bats on southwestern Indian Ocean islands

We provide serological evidence of lyssavirus circulation among bats on southwestern Indian Ocean (SWIO) islands. A total of 572 bats belonging to 22 species were collected on Anjouan, Mayotte, La Réunion, Mauritius, Mahé and Madagascar and screened by the Rapid Fluorescent Focus Inhibition Test for the presence of neutralising antibodies against the two main rabies related lyssaviruses circulating on the African continent: Duvenhage lyssavirus (DUVV) and Lagos bat lyssavirus (LBV), representing phylogroups I and II, respectively. A total of 97 and 42 sera were able to neutralise DUVV and LBV, respectively. No serum neutralised both DUVV and LBV but most DUVV-seropositive bats (n = 32/220) also neutralised European bat lyssavirus 1 (EBLV-1) but not Rabies lyssavirus (RABV), the prototypic lyssavirus of phylogroup I. These results highlight that lyssaviruses belonging to phylogroups I and II circulate in regional bat populations and that the putative phylogroup I lyssavirus is antigenica...

我们提供了西南印度洋（SWIO）岛屿蝙蝠中狂犬病毒属（lyssavirus）循环的血清学证据。我们在昂儒昂岛、马约特岛、留尼汪岛、毛里求斯岛、马埃岛和马达加斯加共采集了22个物种的572只蝙蝠，并通过快速荧光灶抑制试验（Rapid Fluorescent Focus Inhibition Test）筛查其是否存在针对非洲大陆流行的两种主要狂犬病相关狂犬病毒属病毒的中和抗体：分别代表系统发育群I和II的杜文黑格狂犬病毒（Duvenhage lyssavirus，DUVV）和拉各斯蝙蝠狂犬病毒（Lagos bat lyssavirus，LBV）。共有97份和42份血清分别能够中和DUVV和LBV。没有血清同时中和DUVV和LBV，但大多数DUVV血清阳性蝙蝠（n=32/220）也能中和欧洲蝙蝠狂犬病毒1型（European bat lyssavirus 1，EBLV-1），但不能中和系统发育群I的原型狂犬病毒属病毒——狂犬病毒（Rabies lyssavirus，RABV）。这些结果表明，属于系统发育群I和II的狂犬病毒属病毒在区域蝙蝠种群中循环，且推测的系统发育群I狂犬病毒属病毒具有抗原性...