AUD Biomarkers Study (Proteomic and Genomic Analysis of Biospecimens)

Study purpose: to explore the entire spectrum of proteomic and genomic changes (amongst others) involved in diseases and in healthy/control populations. The Study is designed to discover biomarkers, develop and validate diagnostic assays, instruments and therapeutics as well as other medical research. Specifically, researchers may analyze proteins, RNA, DNA copy number changes, including large and small (1,000-100,000 kb) scale rearrangements, transcription profiles, epigenetic modifications, sequence variation, and sequence in both diseased tissue and case-matched germline DNA from Subjects.

研究目的：全面解析与疾病及健康/对照人群相关的蛋白质组学（proteomic）与基因组学（genomic）变化及其他相关生物学变化的完整谱图。本研究旨在发现生物标志物（biomarker）、开发并验证诊断检测试剂、仪器与治疗方案，同时开展其他相关医学研究。具体而言，研究人员可针对病变组织与匹配受试者的种系DNA（germline DNA）开展多维度分析，包括蛋白质、RNA、DNA拷贝数变化、规模介于1000至100000千碱基对的染色体重排、转录谱、表观遗传修饰、序列变异及序列特征。