Twins TS08

This resource describes fundamental features of the immune system (frequency of leukocyte subpopulations, cell surface protein expression) in a large cohort of twins. An accompanying manuscript uses a complementary dataset (link to be provided) to describe the association between immunophenotypes and gene variants (based on single nucleotide polymorphisms (SNPs)).
Conclusion:
The study of immunophenotypes in the context of genome wide association studies can provide mechanistic information about genetic control of normal human immunity and disease.

本数据集描述了大型双胞胎队列中免疫系统的基本特征，涵盖白细胞亚群（leukocyte subpopulations）频率与细胞表面蛋白表达（cell surface protein expression）水平。随附研究手稿将采用互补数据集（链接待提供），解析免疫表型（immunophenotypes）与基于单核苷酸多态性（single nucleotide polymorphisms, SNPs）的基因变异之间的关联。

结论：
在全基因组关联研究（genome wide association studies）框架下开展免疫表型研究，可获取调控正常人类免疫与疾病的遗传机制相关信息。