Electroacupuncture Alleviates Ulcerative Colitis by Targeting CXCL1: Evidence from the Transcriptome and Validation

We aimed to use transcriptomics, bioinformatics analysis, and core gene validation to identify the core gene and potential mechanisms for electroacupuncture (EA) treatment of mice with ulcerative colitis (UC). The Full-length transcriptome was used for sequencing and analysis Comparative gene expression profiling analysis of Full-length transcriptome for colon tissue of mice(CON,DSS,EAST36).

本研究旨在通过转录组学(transcriptomics)、生物信息学分析及核心基因验证，明确电针(EA)治疗溃疡性结肠炎(UC)模型小鼠的核心基因及其潜在作用机制。本研究采用全长转录组(full-length transcriptome)进行测序与分析，并对对照组(CON)、葡聚糖硫酸钠模型组(DSS)及电针足三里(EA-ST36)组小鼠的结肠组织全长转录组开展比较基因表达谱分析。