Molecular changes in skeltal muscle tissue after fatal COVID-19

This retrospective cohort study involved unvaccinated patients admitted to a private hospital in Curitiba, Paraná, Brazil, diagnosed with COVID-19 and died as a result of SARS-CoV-2 infection. Muscle tissue samples were obtained post-mortem when legal representatives signed an informed consent form. The Ethics Committee of the Pontifical Catholic University of Paraná, Brazil (protocol number: 44334921.4.0000.0020) granted ethical approval.

本回顾性队列研究纳入巴西巴拉那州库里提巴市一家私立医院收治的未接种疫苗、确诊新型冠状病毒肺炎（COVID-19）且因严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染死亡的患者。研究人员在死者法定代理人签署知情同意书后，于死后获取其肌肉组织样本。巴西巴拉那州教皇天主教大学（Pontifical Catholic University of Paraná）伦理委员会（协议编号：44334921.4.0000.0020）已批准本研究。