Comparisons of predicted essential enzymes encoding genes shared by all three Category A agents to experimentally identified essential genes across various pathogenic bacteria.

Vc: Vibrio cholera N116961, Bs: Bacillus subtilis 168, Ec: E. coli MG1655, Hi: Haemophilus influenzae Rd KW20, Sp: Streptococcus pneumoniae, Fn: Francisella tularensis sub spp novicida U112, Ab: Acinetobacter baylyi ADP1, Pa: Pseudomonas aeruginosa UCBPP-PA14, Se: Salmonella enterica serv Typhi, Sa: Staphylococcus aureus N315, Mg: Mycoplasma genitalium G37, Mt: Mycobacterium tuberculosis H37Rv, Mp: Mycoplasma pulmonis UAB CTIP and Hp: Helicobacter pylori 26695. “+” Indicates as essential, “− ” Indicates as non-essential.

以下为各菌株的标识及对应信息：Vc为霍乱弧菌（Vibrio cholera）N116961；Bs为枯草芽孢杆菌（Bacillus subtilis）168；Ec为大肠杆菌（E. coli）MG1655；Hi为流感嗜血杆菌（Haemophilus influenzae）Rd KW20；Sp为肺炎链球菌（Streptococcus pneumoniae）；Fn为土拉弗朗西斯菌新亚种（Francisella tularensis subsp. novicida）U112；Ab为鲍曼不动杆菌（Acinetobacter baylyi）ADP1；Pa为铜绿假单胞菌（Pseudomonas aeruginosa）UCBPP-PA14；Se为肠炎沙门氏菌（Salmonella enterica血清型Typhi）；Sa为金黄色葡萄球菌（Staphylococcus aureus）N315；Mg为生殖支原体（Mycoplasma genitalium）G37；Mt为结核分枝杆菌（Mycobacterium tuberculosis）H37Rv；Mp为肺炎支原体（Mycoplasma pulmonis）UAB CTIP；Hp为幽门螺杆菌（Helicobacter pylori）26695。其中符号“+”表示必需，“−”表示非必需。