Deciphering the molecular mechanisms of action of p-cresol sulfate and new chemical entities for the treatment of allergic diseases

Asthma occurs when the lungs release signals that attract immune cells, causing inflammation, swelling, mucus buildup, and airway constriction, making it difficult to breathe. Our lab discovered a molecule produced by gut bacteria that can help reduce these signals. We used this molecule as a starting point to design a potential new drug to treat asthma. My PhD research identified how this drug affects lung cells by interfering with inflammation-triggering signals. We also investigated if this drug could treat eczema through lab-grown skin models. This work provides insight into the drug’s mechanism of action and its potential as a new treatment for allergic diseases.