Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases
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Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases Descriptor: N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-3-SULFANYLPROPANAMIDE, O-GLCNACASE NAGJ Authors: Dorfmueller, H.C, Borodkin, V.S, Schimpl, M, Zheng, X, Kime, R, Read, K.D, van Aalten, D.M.F. Deposit date: 2010-08-26 Release date: 2011-03-16 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Cell-Penetrant, Nanomolar O-Glcnacase Inhibitors Selective Against Lysosomal Hexosaminidases. Chem.Biol, 17, 2010
具备细胞渗透性、纳摩尔级、针对溶酶体己糖胺酶具有选择性的O-连接β-N-乙酰葡糖胺酶（O-GlcNAcase）抑制剂
描述项：N-[(5R,6R,7R,8S)-6,7-二羟基-5-(羟甲基)-2-(2-苯乙基)-5,6,7,8-四氢咪唑并[1,2-a]吡啶-8-基]-3-巯基丙酰胺，O-GlcNAcase NAGJ
作者：Dorfmueller, H.C, Borodkin, V.S, Schimpl, M, Zheng, X, Kime, R, Read, K.D, van Aalten, D.M.F.
入库日期：2010-08-26
发布日期：2011-03-16
最后修改日期：2023-12-20
检测方法：X射线衍射（2.4 Å）
引用文献：Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective Against Lysosomal Hexosaminidases. Chem.Biol, 17, 2010
创建时间：
2010-08-26
