PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3C Protease in complex with Z1198162455

Protein Data Bank Japan2024-10-16 更新2026-03-21 收录

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PanDDA analysis group deposition -- Crystal Structure of Enterovirus D68 3C Protease in complex with Z1198162455 Descriptor: 1-(1-ethyl-1H-pyrazol-3-yl)-N-methylmethanamine, DIMETHYL SULFOXIDE, Protease 3C Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Godoy, A.S, Marples, P.G, Ni, X, Tomlinson, C.W.E, Thompson, W, Wild, C, Fearon, D, Walsh, M.A, von Delft, F. Deposit date: 2023-08-24 Release date: 2023-11-29 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

PanDDA分析团队提交数据集——肠道病毒D68型3C蛋白酶（Protease 3C）与配体Z1198162455的复合物晶体结构。描述：配体为1-(1-乙基-1H-吡唑-3-基)-N-甲基甲胺，体系含二甲基亚砜（DIMETHYL SULFOXIDE）及3C蛋白酶。作者：Lithgo, R.M.、Fairhead, M.、Koekemoer, L.、Aschenbrenner, J.C.、Balcomb, B.H.、Godoy, A.S.、Marples, P.G.、Ni, X.、Tomlinson, C.W.E.、Thompson, W.、Wild, C.、Fearon, D.、Walsh, M.A.、von Delft, F. 提交日期：2023-08-24 发布日期：2023-11-29 最后修改日期：2024-10-16 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.53 Å 引用文献：《柯萨奇病毒A16型2A蛋白酶的晶体片段筛选为广谱抗肠道病毒药物开发提供新方向》，BioRxiv，2024

创建时间：

2023-08-24