Emergence and rapid expansion of pneumococcal serotype 7C due to clonal expansion of sequence type 177 (ST177). ST177 7C

Serotype 7C is a rare cause of invasive pneumococcal disease (IPD) in England and Wales. However, in early 2017, we observed a sudden and rapid increase in 7C IPD due to what was almost entirely an association with clonal expansion of ST177, and ST previously associated with vaccine serotype 19F. We carried out epidemiological and genomic investigations on the 7C strains.

血清型7C（Serotype 7C）在英格兰与威尔士是侵袭性肺炎球菌疾病（invasive pneumococcal disease, IPD）的罕见致病原。2017年初，我们却观测到7C型侵袭性肺炎球菌疾病的病例数出现突发且快速的攀升，该增长几乎完全与序列型177（ST177）的克隆扩增相关，而这类ST177菌株此前便与疫苗血清型19F存在关联。后续我们针对7C型菌株开展了流行病学与基因组学调查。